雜志的主要焦點是數值線性代數，近似理論及其應用，微分和積分方程的數值解，計算復雜性，算法，計算機科學的數學方面，和最優化理論。Calcolo包含介紹新興主題的說明性論文，以及博士論文摘要、會議新聞和報告，以及書評。

The main focus of the journal is on numerical linear algebra, approximation theory and its applications, numerical solutions of differential and integral equations, computational complexity, algorithmics, mathematical aspects of computer science, and optimization theory.Calcolo contains expository papers which introduce emerging topics as well as a abstracts of PhD theses, news and reports from conferences, and book reviews.