計算機和數學及其應用為從事有助于利用偏微分方程（PDE）為科學和工程建立成功模擬的領域的人們提供了一種交換媒介。以下是本刊關注的主要領域：使用PDE建模。根據偏微分方程建立的數學模型分析。偏微分方程的離散化方法和數值分析。數值線性和非線性代數。快速數字算法。算法和數據結構。適應性。計算幾何。軟件設計、代碼驗證和質量保證（QA）。驗證和確認。

Computers & Mathematics with Applications provides a medium of exchange for those engaged in fields contributing to building successful simulations for science and engineering using Partial Differential Equations (PDEs). The following are the principal areas of interest of the journal:Modeling using PDEs.Analysis of mathematical models, formulated in terms of PDEs.Discretization Methods and Numerical Analysis for PDEs.Numerical linear and nonlinear algebra. Fast numerical algorithms.Algorithms and Data Structures. Adaptivity. Computational Geometry.Software Design, Code verification and Quality Assurance (QA).Verification and Validation.