在過去的幾十年里，細胞遺傳學和基因組研究一直是人類和動物細胞遺傳學(包括分子遺傳學、臨床遺傳學和比較細胞遺傳學)原始報告和評論的主要論壇。近年來，其研究領域主要集中在基因克隆與測序、基因定位、基因調控與表達、癌癥遺傳學、比較遺傳學、基因連鎖等領域。該雜志還發表了關于體細胞、減數分裂細胞和惡性細胞染色體畸變的重要論文。其范圍已擴大到包括無脊椎動物和植物細胞遺傳學和基因組學的研究。此外，最近有關人類和動物染色體命名法的國際報告以及關于家畜基因定位的報告也很有特色。除了定期出版的期刊外，自2002年以來，該雜志還出版了一系列關于細胞遺傳學和基因組研究等廣泛主題的專題期刊。

During the last decades, Cytogenetic and Genome Research has been the leading forum for original reports and reviews in human and animal cytogenetics, including molecular, clinical and comparative cytogenetics. In recent years, most of its papers have centered on genome research, including gene cloning and sequencing, gene mapping, gene regulation and expression, cancer genetics, comparative genetics, gene linkage and related areas. The journal also publishes key papers on chromosome aberrations in somatic, meiotic and malignant cells. Its scope has expanded to include studies on invertebrate and plant cytogenetics and genomics. Also featured are recent international reports on human and animal chromosome nomenclature and reports on gene mapping in domestic animals. In addition to regular issues, the journal has been publishing since 2002 a series of topical issues on a broad variety of themes from cytogenetic and genome research.