IEEE/ACM《計算生物學與生物信息學學報》強調在生物信息學和計算生物學中處于核心地位的算法、數學、統計和計算方法;生物信息學中有效計算機程序的開發與測試發展生物數據庫;以及利用這些方法、程序和數據庫獲得的重要生物學結果;系統生物學的新興領域，其中許多形式的數據被用來創建一個基于計算機的復雜生物系統模型。該出版物代表了三種研究模式的混合:a)由生物學問題直接推動的基本方法學、算法、數學和統計研究;b)重點研究實驗和實施問題的論文;c)關于認真應用方法和程序，從而發現具有生物學意義的論文。越來越多的論文包含了所有三種模式的要素。感興趣的具體主題包括但不限于序列分析、比較和對齊方法;基序、基因和信號識別;分子進化;系統遺傳學和系統基因組學;二、三維RNA和蛋白質結構的測定或預測;DNA扭曲和折疊;基因表達與基因調控網絡代謝途徑的推斷;微陣列設計與分析;蛋白質組學;功能基因組學;分子對接與藥物設計;遺傳計算問題，如連鎖和QTL分析，群體連鎖不平衡分析，單倍型確定;系統生物學。

IEEE/ACM Transactions on Computational Biology and Bioinformatics emphasizes the algorithmic, mathematical, statistical, and computational methods that are central in bioinformatics and computational biology; the development and testing of effective computer programs in bioinformatics; the development of biological databases; and important biological results that are obtained from the use of these methods, programs and databases; the emerging field of Systems Biology, where many forms of data are used to create a computer-based model of a complex biological system. The publication represents a mixture of three research modalities: a) fundamental methodological, algorithmic, mathematical and statistical research directly motivated by biological issues; b) papers focusing on experimental and implementation issues; and c) papers on serious application of methods and programs that lead to discoveries of biological significance. Increasingly, papers contain elements of all three modalities. Specific topics of interest include, but are not limited to, sequence analysis, comparison and alignment methods; motif, gene and signal recognition; molecular evolution; phylogenetics and phylogenomics; determination or prediction of the structure of RNA and Protein in two and three dimensions; DNA twisting and folding; gene expression and gene regulatory networks; deduction of metabolic pathways; micro-array design and analysis; proteomics; functional genomics; molecular docking and drug design; computational problems in genetics such as linkage and QTL analysis, linkage disequilibrium analysis in populations, and haplotype determination; systems biology.