心血管疾病進展的每一期都全面涵蓋了理解和治療心臟和循環障礙的單一主題。一些問題包括特殊的文章，明確的評論，捕捉在心臟病學的特殊臨床問題的管理的最先進的狀態。每卷至少出現兩次的專題文章比較了心臟病學家和內科醫師感興趣的單一治療問題的臨床試驗。

Each issue of Progress in Cardiovascular Diseases comprehensively covers a single topic in the understanding and treatment of disorders of the heart and circulation. Some issues contain special articles, definitive reviews that capture the state-of-the-art in the management of particular clinical problems in cardiology. Also appearing at least twice per volume is a feature article comparing clinical trials of a single therapeutic problem of interest to cardiologists and internal medicine physicians.